As cirrhosis progresses, more and more scar tissue forms, making it difficult for the liver to function (decompensated cirrhosis). COVID-19 is an emerging, rapidly evolving situation. Accessed Nov. 28, 2018. A wide range of diseases and conditions can damage the liver and lead to cirrhosis. Accessed Nov. 25, 2018. People with cirrhosis … Berzigotti A. In the process, scar tissue forms. Accessed Nov. 25, 2018. Hernaez R, et al. Accessed Nov. 26, 2018. Philadelphia, Pa.: Saunders Elsevier; 2016. 10th ed. In: Conn's Current Therapy 2018. Accessed Nov. 27, 2018. Allscripts EPSi. Swelling in your legs, feet or ankles (edema) 6. feeling tired or weak. Cirrhosis. Cirrhosis. A normal liver (left) shows no signs of scarring. As liver function gets worse, you may have other symptoms, including. Each time your liver is injured — whether by disease, excessive alcohol consumption or another cause — it tries to repair itself. Mayo Clinic is a not-for-profit organization. Evaluation for liver transplantation in adults: 2013 practice guideline by the AASLD and the American Society of Transplantation. The most common causes of Cirrhosis are Hepatitis C, Alcohol-related Liver Disease, Non-Alcoholic Fatty Liver Disease, and Hepatitis B.; Many people with Cirrhosis … Some people with cirrhosis have more than one cause of liver damage. Merck Manual Professional Version. Fever. Cirrhosis refers to the replacement of normal liver tissue with non-living scar tissue.It is always related to other liver diseases. Easily bleeding or bruising 3. Feldman M, et al. Fatigue 2. Advances and challenges in cirrhosis and portal hypertension. All rights reserved. The liver damage done by cirrhosis generally can't be undone. Brown AY. Redness in the palms of the hands 12. What are the symptoms of cirrhosis? Alcohol has a toxic effect on liver cells. Hours: 8:30 a.m. to 5 p.m. Eastern time, M-F. NIH staff guidance on coronavirus (NIH Only): U.S. Department of Health and Human Services,, National Institute of Diabetes and Digestive and Kidney Diseases, mild pain or discomfort in the upper right side of your, confusion, difficulties thinking, memory loss, personality changes, or sleep disorders, swelling in your lower legs, ankles, or feet, called, yellowish tint to the whites of your eyes and skin, called, alcoholic liver disease—damage to the liver and its function due to, inherited liver diseases—diseases passed from parents to children through genes—that affect how the liver works, such as. Severe muscle cramps. Make a donation. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, See our safety precautions in response to COVID-19, FREE book offer – Mayo Clinic Health Letter. The options include: Treatment for alcohol dependency. Martin P, et al. This content does not have an English version. Cirrhosis has different causes. Overview of cirrhosis. Yellow discoloration in the skin and eyes (jaundice) 9. Accessed Nov. 28, 2018. Cirrhosis has many causes. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Litin SC (expert opinion). American Gastroenterological Association. Accessed Nov. 27, 2018. Weight loss 7. The most common causes of liver cirrhosis include: Long-term hepatitis infections (chronic): One of the major causes of liver disease, hepatitis is a viral infection which causes inflammation of the liver. Enlarged spleen. National Institute of Diabetes and Digestive and Kidney Diseases. Advanced cirrhosis is life-threatening. Loss of appetite 4. But if liver cirrhosis is diagnosed early and the cause is treated, further damage can be limited and, rarely, reversed. Cirrhosis in adults: Overview of complications, general management, and prognosis. This site complies with the HONcode standard for trustworthy health information: verify here. Mayo Clinic does not endorse companies or products. National Organization for Rare Disorders. Cirrhosis often has no signs or symptoms until liver damage is extensive. American College of Gastroenterology.